The questions below are the ones researchers ask most about storing, mixing and handling kisspeptin-10. Each answer reflects the peptide’s sequence, Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2, and links to the fuller page where there is one.
How long does kisspeptin last in the fridge after mixing?
Mixed with bacteriostatic water and kept at 2 to 8 °C in the dark, kisspeptin-10 lasts 8 to 12 weeks under Vistara Labs’ handling guidance, with quality slowly fading from around week 6 to 8. No published study covers it in a sterile solution, so the window is general peptide guidance. The full table is on how long kisspeptin lasts.
How long does unmixed kisspeptin powder last?
A sealed lyophilised vial keeps for the weeks it is in use at 2 to 8 °C and for a year or more frozen, dry and dark, where a supplier rates it. The dry cake has almost no water, so deamidation and oxidation have little to work with. Days at room temperature in transit do not harm it, so it ships without an ice pack.
Is kisspeptin-10 the same as kisspeptin?
It is the last ten residues of it. The natural hormone, first isolated as metastin, has 54 residues with an amidated end (Ohtaki et al., Nature, 2001). Kisspeptin-10 is positions 45 to 54, the shortest form that keeps receptor activity, and it is what our vials and spray contain. More in what is kisspeptin.
Why does kisspeptin break down so fast in blood?
Enzymes. In rat plasma it lost its first tyrosine with a half-life of minutes (Liu et al., Journal of Chromatography B, 2013), and serum enzymes also cut it near Phe6 and Gly7 (Asami et al., Bioorganic and Medicinal Chemistry Letters, 2012). A sterile vial contains no enzymes, so those figures do not describe a mixed vial; they are why sterile access matters.
What are kisspeptin-10’s weak points in a vial?
Two asparagines, at positions 2 and 4, that can slowly deamidate, and a tryptophan and a tyrosine that can oxidise, driven by light, warmth and trace metals. It has no methionine or cysteine. Cold, dark storage slows all of these. The details are on the kisspeptin stability page.
What do you mix kisspeptin with?
Bacteriostatic water, which is sterile water with 0.9% benzyl alcohol so a refrigerated vial can be accessed more than once. Kisspeptin-10 carries two positive charges at that pH, so it dissolves without acid, though its aromatic residues make gentle swirling important. The reasons are on the kisspeptin solubility guide.
How much bacteriostatic water goes in a 10 mg kisspeptin vial?
There is no single correct volume. With 2 mL a 10 mg vial gives 5 mg/mL; with 1 mL it gives 10 mg/mL. More water spreads the same amount of peptide through a larger volume, so write the chosen concentration on the vial. The tables and calculator are on the kisspeptin reconstitution page.
Why is my kisspeptin cloudy after mixing?
Brief cloudiness that clears within 10 to 15 minutes is usually trapped air from adding water too fast or shaking. Haze that persists, particles or a tint that appears later point to warm storage, light, freezing or contamination, and the solution is discarded. More in why peptides gel or go cloudy.
Does kisspeptin need to be kept out of the light?
Yes, more than most peptides in this series. It has four aromatic residues, a tyrosine, a tryptophan and two phenylalanines, which absorb ultraviolet light, and tryptophan and tyrosine are among the residues most open to oxidation. Keep the vial boxed in the main body of the fridge.
How is the kisspeptin nasal spray stored?
It arrives ready-mixed in bacteriostatic water in a sealed metered pump, so it goes into the fridge upright, capped and dark as soon as it arrives, is dated when first opened and is never frozen. The vial’s after-mixing window does not carry over to the spray. More in how to store a peptide nasal spray.
All products supplied by Vistara Labs are intended for laboratory research use only. They are not drugs, are not approved for human or veterinary use, and are not intended to diagnose, treat, cure or prevent any condition. Nothing on this page constitutes medical advice or guidance for use in humans.
